› 4l9k

X-ray diffraction
2.4Å resolution

X-ray study of human serum albumin complexed with camptothecin

Released:
DOI: 10.2210/pdb4l9k/pdb
PDB entry 4l9k coloured by chain, front view.
PDB entry 4l9k coloured by chain, side view.
PDB entry 4l9k coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural studies of several clinically important oncology drugs in complex with human serum albumin.
Wang ZM, Ho JX, Ruble JR, Rose J, Rüker F, Ellenburg M, Murphy R, Click J, Soistman E, Wilkerson L, Carter DC
Biochim Biophys Acta 1830 5356-74 (2013)
PMID: 23838380

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136176 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Albumin Chains: A, B
Molecule details ›
Chains: A, B
Length: 585 amino acids
Theoretical weight: 66.57 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02768 (Residues: 25-609; Coverage: 99%)
Gene names: ALB, GIG20, GIG42, PRO0903, PRO1708, PRO2044, PRO2619, PRO2675, UNQ696/PRO1341
Sequence domains: Serum albumin family
Structure domains: Serum Albumin; Chain A, Domain 1

Ligands and Environments

1 bound ligand:
Ligand EHF 2 x EHF
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P1
Unit cell:
a: 58.974Å b: 59.457Å c: 96.039Å
α: 74.97° β: 87.9° γ: 75.48°
R-values:
R R work R free
0.216 0.214 0.269

Quick links

Citations

8 review citations

Human serum albumin, systemic inflammation, and cirrhosis.
Arroyo et al. (2014)
7 more

6 mentions without citation

Quantum computing algorithms: getting closer to critical problems in computational biology.
Marchetti et al. (2022)
5 more