› 4lce

X-ray diffraction
2.38Å resolution

CtBP1 in complex with substrate MTOB

Released:
DOI: 10.2210/pdb4lce/pdb
PDB entry 4lce coloured by chain, front view.
PDB entry 4lce coloured by chain, side view.
PDB entry 4lce coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of human CtBP in complex with substrate MTOB reveal active site features useful for inhibitor design.
Hilbert BJ, Grossman SR, Schiffer CA, Royer WE
FEBS Lett 588 1743-8 (2014)
PMID: 24657618

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171656 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
C-terminal-binding protein 1 Chain: A
Molecule details ›
Chain: A
Length: 347 amino acids
Theoretical weight: 38.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q13363 (Residues: 28-353; Coverage: 74%)
Gene names: CTBP, CTBP1
Sequence domains:
Structure domains: NAD(P)-binding Rossmann-like Domain

Ligands and Environments

2 bound ligands:
Ligand NAD 1 x NAD
Ligand KMT 1 x KMT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-BM-C
Spacegroup: P6422
Unit cell:
a: 88.97Å b: 88.97Å c: 161.538Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.202 0.2 0.239
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

CtBP- an emerging oncogene and novel small molecule drug target: Advances in the understanding of its oncogenic action and identification of therapeutic inhibitors.
Dcona et al. (2017)
2 more

5 mentions without citation

Hallmarks of Pulmonary Hypertension: Mesenchymal and Inflammatory Cell Metabolic Reprogramming.
D'Alessandro et al. (2018)
4 more