› 4lcy

X-ray diffraction
1.6Å resolution

Crystal structure of HLA-b46 at 1.6 angstrom resolution

Released:
DOI: 10.2210/pdb4lcy/pdb
PDB entry 4lcy coloured by chain, front view.
PDB entry 4lcy coloured by chain, side view.
PDB entry 4lcy coloured by chain, top view.
Source organisms:
Entry author: Liu JX

Function and Biology Details

Reactions catalysed: 
S-adenosyl-L-methionine + a 5'-(5'-triphosphoguanosine)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA]
S-adenosyl-L-methionine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(ribonucleotide)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleotide)-[mRNA]
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Selective hydrolysis of -Xaa-Xaa-|-Yaa- bonds in which each of the Xaa can be either Arg or Lys and Yaa can be either Ser or Ala.
NTP + H(2)O = NDP + phosphate
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-135156 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
HLA class I histocompatibility antigen, B alpha chain Chains: A, F
Molecule details ›
Chains: A, F
Length: 274 amino acids
Theoretical weight: 31.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01889 (Residues: 25-298; Coverage: 81%)
Gene names: HLA-B, HLAB
Sequence domains:
Structure domains:
Beta-2-microglobulin Chains: B, H
Molecule details ›
Chains: B, H
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Serine protease NS3 Chains: C, J
Molecule details ›
Chains: C, J
Length: 9 amino acids
Theoretical weight: 1.06 KDa
Source organism: dengue virus type 1
Expression system: Not provided
UniProt:
  • Canonical: P17763 (Residues: 1741-1749; Coverage: 0%)

Ligands and Environments

1 bound ligand:
Ligand NA 6 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE BL13B1
Spacegroup: P21
Unit cell:
a: 49.95Å b: 89.73Å c: 94.62Å
α: 90° β: 98.45° γ: 90°
R-values:
R R work R free
0.174 0.172 0.201
Expression systems:
  • Escherichia coli
  • Not provided

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