› 4ldr

X-ray diffraction
2.29Å resolution

Structure of the S283Y mutant of MRDI

Released:
DOI: 10.2210/pdb4ldr/pdb
PDB entry 4ldr coloured by chain, front view.
PDB entry 4ldr coloured by chain, side view.
PDB entry 4ldr coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of mediator of RhoA-dependent invasion (MRDI) explains its dual function as a metabolic enzyme and a mediator of cell invasion.
Templeton PD, Litman ES, Metzner SI, Ahn NG, Sousa MC
Biochemistry 52 5675-84 (2013)
PMID: 23859498

Function and Biology Details

Reaction catalysed: 
S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189748 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Methylthioribose-1-phosphate isomerase Chains: A, B
Molecule details ›
Chains: A, B
Length: 369 amino acids
Theoretical weight: 39.27 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q9BV20 (Residues: 1-369; Coverage: 100%)
Gene names: MRDI, MRI1, UNQ6390/PRO21135
Sequence domains: Initiation factor 2 subunit family
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P212121
Unit cell:
a: 44.518Å b: 115.97Å c: 135.5Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.181 0.18 0.208
Expression system: Not provided

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