› 4lgg

X-ray diffraction
2.41Å resolution

Structure of 3MB-PP1 bound to analog-sensitive Src kinase

Released:
DOI: 10.2210/pdb4lgg/pdb
PDB entry 4lgg coloured by chain, front view.
PDB entry 4lgg coloured by chain, side view.
PDB entry 4lgg coloured by chain, top view.
Source organism: Gallus gallus
Primary publication:
Structure-guided inhibitor design expands the scope of analog-sensitive kinase technology.
Zhang C, Lopez MS, Dar AC, Ladow E, Finkbeiner S, Yun CH, Eck MJ, Shokat KM
ACS Chem Biol 8 1931-8 (2013)
PMID: 23841803

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132629 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Proto-oncogene tyrosine-protein kinase Src Chains: A, B
Molecule details ›
Chains: A, B
Length: 270 amino acids
Theoretical weight: 30.92 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli
UniProt:
  • Canonical: P00523 (Residues: 264-533; Coverage: 51%)
Gene name: SRC
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand VGG 2 x VGG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: P1
Unit cell:
a: 41.988Å b: 55.815Å c: 62.978Å
α: 89.98° β: 90.06° γ: 88.86°
R-values:
R R work R free
0.238 0.235 0.285
Expression system: Escherichia coli

Quick links

Citations

8 review citations

Targeting cyclin-dependent kinases in human cancers: from small molecules to Peptide inhibitors.
Peyressatre et al. (2015)
7 more

3 mentions without citation

Structure-guided inhibitor design expands the scope of analog-sensitive kinase technology.
Zhang et al. (2013)
2 more