Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
Assembly name:
Thioredoxin-interacting protein and Thioredoxin (preferred)
PDBe Complex ID:
PDB-CPX-145353 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Thioredoxin-interacting protein
Molecule details ›
Chains: A, C
Length: 315 amino acids
Theoretical weight: 35.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains:
Structure domains: Immunoglobulin-like
Length: 315 amino acids
Theoretical weight: 35.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
Q9H3M7 (Residues: 3-317; Coverage: 81%)
Sequence domains:
Structure domains: Immunoglobulin-like
Thioredoxin
Molecule details ›
Chains: B, D
Length: 105 amino acids
Theoretical weight: 11.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Thioredoxin
Structure domains: Glutaredoxin
Length: 105 amino acids
Theoretical weight: 11.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P10599 (Residues: 1-105; Coverage: 100%)
Sequence domains: Thioredoxin
Structure domains: Glutaredoxin
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
PAL/PLS BEAMLINE 7A (6B, 6C1)
Spacegroup:
P21
Expression system: Escherichia coli
