› 4lli

X-ray diffraction
2.2Å resolution

Crystal Structure of human Myosin 5a globular domain

Released:
DOI: 10.2210/pdb4lli/pdb
PDB entry 4lli coloured by chain, front view.
PDB entry 4lli coloured by chain, side view.
PDB entry 4lli coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into the globular tails of the human type v myosins Myo5a, Myo5b, And Myo5c.
Velvarska H, Niessing D
PLoS One 8 e82065 (2013)
PMID: 24339992

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195241 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Unconventional myosin-Va Chains: A, B
Molecule details ›
Chains: A, B
Length: 395 amino acids
Theoretical weight: 45.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9Y4I1 (Residues: 1467-1855; Coverage: 21%)
Gene names: MYH12, MYO5A
Sequence domains: DIL domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P212121
Unit cell:
a: 74.057Å b: 87.105Å c: 130.933Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.201 0.198 0.246
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

MYO5B, STX3, and STXBP2 mutations reveal a common disease mechanism that unifies a subset of congenital diarrheal disorders: A mutation update.
Dhekne et al. (2018)
2 more

2 mentions without citation

Structural insights into the globular tails of the human type v myosins Myo5a, Myo5b, And Myo5c.
Velvarska et al. (2013)
1 more