› 4lnp

X-ray diffraction
1.41Å resolution

The first SH3 domain from CAP/Ponsin in complex with proline rich peptide from Vinculin

Released:
DOI: 10.2210/pdb4lnp/pdb
PDB entry 4lnp coloured by chain, front view.
PDB entry 4lnp coloured by chain, side view.
PDB entry 4lnp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural investigation of the interaction between the tandem SH3 domains of c-Cbl-associated protein and vinculin.
Zhao D, Wang X, Peng J, Wang C, Li F, Sun Q, Zhang Y, Zhang J, Cai G, Zuo X, Wu J, Shi Y, Zhang Z, Gong Q
J Struct Biol 187 194-205 (2014)
PMID: 24878663

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148325 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Sorbin and SH3 domain-containing protein 1 Chain: A
Molecule details ›
Chain: A
Length: 61 amino acids
Theoretical weight: 7.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9BX66 (Residues: 794-854; Coverage: 5%)
Gene names: KIAA0894, KIAA1296, SH3D5, SORBS1
Sequence domains: Variant SH3 domain
Structure domains: SH3 Domains
Vinculin Chain: B
Molecule details ›
Chain: B
Length: 10 amino acids
Theoretical weight: 1.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P18206 (Residues: 870-879; Coverage: 1%)
Gene name: VCL

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P212121
Unit cell:
a: 24.48Å b: 49.85Å c: 58.94Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.14 0.137 0.194
Expression system: Escherichia coli

Quick links

Citations

7 citation in other articles

SORBS1 suppresses tumor metastasis and improves the sensitivity of cancer to chemotherapy drug.
Song et al. (2017)
6 more