› 4lnx

X-ray diffraction
2.05Å resolution

Crystal structure of TR-alpha bound to T4 in a second site

Released:
DOI: 10.2210/pdb4lnx/pdb
PDB entry 4lnx coloured by chain, front view.
PDB entry 4lnx coloured by chain, side view.
PDB entry 4lnx coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Identification of a new hormone-binding site on the surface of thyroid hormone receptor.
Souza PC, Puhl AC, Martínez L, Aparício R, Nascimento AS, Figueira AC, Nguyen P, Webb P, Skaf MS, Polikarpov I
Mol Endocrinol 28 534-45 (2014)
PMID: 24552590

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145479 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thyroid hormone receptor alpha Chain: A
Molecule details ›
Chain: A
Length: 267 amino acids
Theoretical weight: 30.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P10827 (Residues: 148-370; Coverage: 46%)
Gene names: EAR7, ERBA1, NR1A1, THRA, THRA1, THRA2
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

2 bound ligands:
Ligand T44 1 x T44
Ligand T3 1 x T3
1 modified residue:
Ligand CAS 4 x CAS

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU ULTRAX 18
Spacegroup: P212121
Unit cell:
a: 59.744Å b: 80.924Å c: 101.871Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.157 0.155 0.177
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Thyroid hormone receptor localization in target tissues.
Anyetei-Anum et al. (2018)
6 more

3 mentions without citation

Advances in Computational Polypharmacology.
Feldmann et al. (2022)
2 more