› 4lrh

X-ray diffraction
2.8Å resolution

Crystal structure of human folate receptor alpha in complex with folic acid

Released:
DOI: 10.2210/pdb4lrh/pdb
PDB entry 4lrh coloured by chain, front view.
PDB entry 4lrh coloured by chain, side view.
PDB entry 4lrh coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for molecular recognition of folic acid by folate receptors.
Chen C, Ke J, Zhou XE, Yi W, Brunzelle JS, Li J, Yong EL, Xu HE, Melcher K
Nature 500 486-9 (2013)
PMID: 23851396

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147318 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Folate receptor alpha Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 218 amino acids
Theoretical weight: 25.54 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P15328 (Residues: 23-235; Coverage: 91%)
Gene names: FOLR, FOLR1
Sequence domains: Folate receptor family

Ligands and Environments

2 bound ligands:
Ligand FOL 8 x FOL
Ligand NAG 22 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P212121
Unit cell:
a: 90.021Å b: 144.589Å c: 216.839Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.227 0.227 0.267
Expression system: Homo sapiens

Quick links

Citations

51 review citations

Exploiting the folate receptor α in oncology.
Scaranti et al. (2020)
50 more

25 mentions without citation

Structural basis for molecular recognition of folic acid by folate receptors.
Chen et al. (2013)
24 more