› 4lvt

X-ray diffraction
2.05Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145305 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Apoptosis regulator Bcl-2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 166 amino acids
Theoretical weight: 19.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P10415 (Residues: 1-34, 92-207; Coverage: 63%)
Gene name: BCL2
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand 1XJ 2 x 1XJ
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-BM
Spacegroup: P21
Unit cell:
a: 34.77Å b: 68.08Å c: 65.47Å
α: 90° β: 95.96° γ: 90°
R-values:
R R work R free
0.172 0.169 0.222
Expression system: Escherichia coli

Quick links

Citations

508 review citations

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy.
Czabotar et al. (2014)
507 more

40 mentions without citation

Motif mediated protein-protein interactions as drug targets.
Corbi-Verge et al. (2016)
39 more