› 4lx1

X-ray diffraction
1.87Å resolution

Crystal structure of Myo5a globular tail domain

Released:
DOI: 10.2210/pdb4lx1/pdb
PDB entry 4lx1 coloured by chain, front view.
PDB entry 4lx1 coloured by chain, side view.
PDB entry 4lx1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of myosin V Rab GTPase-dependent cargo recognition.
Pylypenko O, Attanda W, Gauquelin C, Lahmani M, Coulibaly D, Baron B, Hoos S, Titus MA, England P, Houdusse AM
Proc Natl Acad Sci U S A 110 20443-8 (2013)
PMID: 24248336

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195241 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Unconventional myosin-Va Chains: A, B
Molecule details ›
Chains: A, B
Length: 392 amino acids
Theoretical weight: 44.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y4I1 (Residues: 1464-1855; Coverage: 21%)
Gene names: MYH12, MYO5A
Sequence domains: DIL domain

Ligands and Environments

4 bound ligands:
Ligand SO4 8 x SO4
Ligand EDO 1 x EDO
Ligand TRS 1 x TRS
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: P212121
Unit cell:
a: 78.08Å b: 94.58Å c: 135.28Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.166 0.164 0.199
Expression system: Escherichia coli

Quick links

Citations

16 review citations

Orchestration of cell surface proteins by Rab11.
Welz et al. (2014)
15 more

3 mentions without citation

Structural basis of myosin V Rab GTPase-dependent cargo recognition.
Pylypenko et al. (2013)
2 more