› 4lxd

X-ray diffraction
1.9Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145305 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Apoptosis regulator Bcl-2 Chain: A
Molecule details ›
Chain: A
Length: 166 amino acids
Theoretical weight: 19.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P10415 (Residues: 1-34, 92-207; Coverage: 63%)
Gene name: BCL2
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand 1XV 1 x 1XV
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P61
Unit cell:
a: 86.515Å b: 86.515Å c: 62.425Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.182 0.18 0.212
Expression system: Escherichia coli

Quick links

Citations

508 review citations

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy.
Czabotar et al. (2014)
507 more

16 mentions without citation

Interaction of Bcl-2 with the autophagy-related GABAA receptor-associated protein (GABARAP): biophysical characterization and functional implications.
Ma et al. (2013)
15 more