› 4m7c

X-ray diffraction
2.05Å resolution

Crystal structure of the TRF2-binding motif of SLX4 in complex with the TRFH domain of TRF2

Released:
DOI: 10.2210/pdb4m7c/pdb
PDB entry 4m7c coloured by chain, front view.
PDB entry 4m7c coloured by chain, side view.
PDB entry 4m7c coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
SLX4 assembles a telomere maintenance toolkit by bridging multiple endonucleases with telomeres.
Wan B, Yin J, Horvath K, Sarkar J, Chen Y, Wu J, Wan K, Lu J, Gu P, Yu EY, Lue NF, Chang S, Liu Y, Lei M
Cell Rep 4 861-9 (2013)
PMID: 24012755

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172321 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Telomeric repeat-binding factor 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 200 amino acids
Theoretical weight: 23.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15554 (Residues: 87-286; Coverage: 37%)
Gene names: TERF2, TRBF2, TRF2
Sequence domains: Telomere repeat binding factor (TRF)
Structure domains: Telomere repeat-binding factor, dimerisation domain
Structure-specific endonuclease subunit SLX4 Chains: C, D
Molecule details ›
Chains: C, D
Length: 13 amino acids
Theoretical weight: 1.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IY92 (Residues: 1014-1025; Coverage: 1%)
Gene names: BTBD12, KIAA1784, KIAA1987, SLX4

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P21
Unit cell:
a: 32.591Å b: 69.183Å c: 118.078Å
α: 90° β: 94.73° γ: 90°
R-values:
R R work R free
0.216 0.214 0.262
Expression system: Escherichia coli

Quick links

Citations

23 review citations

Molecular mechanisms of activity and derepression of alternative lengthening of telomeres.
Pickett et al. (2015)
22 more

7 mentions without citation

Fanconi anemia pathway as a prospective target for cancer intervention.
Liu et al. (2020)
6 more