› 4m7l

X-ray diffraction
3.4Å resolution

Crystal structure of the complex between human tissue factor extracellular domain and antibody 10H10 FAB fragment

Released:
DOI: 10.2210/pdb4m7l/pdb
PDB entry 4m7l coloured by chain, front view.
PDB entry 4m7l coloured by chain, side view.
PDB entry 4m7l coloured by chain, top view.
Source organisms:
Entry authors: Teplyakov A, Obmolova G, Malia T, Gilliland GL

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-210557 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Tissue factor Chain: T
Molecule details ›
Chain: T
Length: 215 amino acids
Theoretical weight: 24.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P13726 (Residues: 37-245; Coverage: 80%)
Gene name: F3
Sequence domains:
Structure domains: Immunoglobulins
10H10 light chain Chain: L
Molecule details ›
Chain: L
Length: 220 amino acids
Theoretical weight: 24.14 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
Structure domains: Immunoglobulins
10H10 heavy chain Chain: H
Molecule details ›
Chain: H
Length: 229 amino acids
Theoretical weight: 24.42 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
1 modified residue:
Ligand PCA 1 x PCA

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: I41
Unit cell:
a: 116.86Å b: 116.86Å c: 106.86Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.245 0.242 0.289
Expression systems:
  • Escherichia coli
  • Homo sapiens

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