› 4mdd

X-ray diffraction
2.4Å resolution

Crystal Structure of the Glucocorticoid Receptor Bound to a Non-steroidal Antagonist Reveals Repositioning and Partial Disordering of Activation Function Helix 12

Released:
DOI: 10.2210/pdb4mdd/pdb
PDB entry 4mdd coloured by chain, front view.
PDB entry 4mdd coloured by chain, side view.
PDB entry 4mdd coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Coghlan MJ, Luz JG

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130928 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Glucocorticoid receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 258 amino acids
Theoretical weight: 29.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04150 (Residues: 522-777; Coverage: 33%)
Gene names: GRL, NR3C1
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Nuclear receptor corepressor 1 Chains: C, D
Molecule details ›
Chains: C, D
Length: 15 amino acids
Theoretical weight: 1.63 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: O75376 (Residues: 2260-2274; Coverage: 1%)
Gene names: KIAA1047, NCOR1

Ligands and Environments

1 bound ligand:
Ligand 29M 2 x 29M
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: P3221
Unit cell:
a: 72.543Å b: 72.543Å c: 229.472Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.222 0.221 0.258
Expression systems:
  • Escherichia coli
  • Not provided

Quick links