› 4muc

X-ray diffraction
2.9Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169920 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Complement factor H-related protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 125 amino acids
Theoretical weight: 14.24 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: Q03591 (Residues: 205-329; Coverage: 40%)
Gene names: CFHL, CFHL1, CFHL1P, CFHR1, CFHR1P, FHR1, HFL1, HFL2
Sequence domains: Sushi repeat (SCR repeat)
Structure domains: Complement Module, domain 1

Ligands and Environments

1 bound ligand:
Ligand SO4 7 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P622
Unit cell:
a: 143.406Å b: 143.406Å c: 77.784Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.213 0.207 0.269
Expression system: Komagataella pastoris

Quick links

Citations

12 review citations

HUS and atypical HUS.
Jokiranta TS. (2017)
11 more

2 mentions without citation

The major autoantibody epitope on factor H in atypical hemolytic uremic syndrome is structurally different from its homologous site in factor H-related protein 1, supporting a novel model for induction of autoimmunity in this disease.
Bhattacharjee et al. (2015)
1 more