› 4myg

X-ray diffraction
2.59Å resolution

MAPK13, active form

Released:
DOI: 10.2210/pdb4myg/pdb
PDB entry 4myg coloured by chain, front view.
PDB entry 4myg coloured by chain, side view.
PDB entry 4myg coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structure of phosphorylated MAPK13 reveals common structural features and differences in p38 MAPK family activation.
Yurtsever Z, Scheaffer SM, Romero AG, Holtzman MJ, Brett TJ
Acta Crystallogr D Biol Crystallogr 71 790-9 (2015)
PMID: 25849390

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127397 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 13 Chains: A, B
Molecule details ›
Chains: A, B
Length: 372 amino acids
Theoretical weight: 42.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O15264 (Residues: 1-352; Coverage: 96%)
Gene names: MAPK13, PRKM13, SAPK4
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

No bound ligands
2 modified residues:
Ligand TPO 2 x TPO
Ligand PTR 2 x PTR

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 4.2.2
Spacegroup: P65
Unit cell:
a: 107.232Å b: 107.232Å c: 125.531Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.207 0.205 0.255
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

p38γ and p38δ: From Spectators to Key Physiological Players.
Cuenda et al. (2017)
2 more

5 mentions without citation

A Special View of What Was Almost Forgotten: p38δ MAPK.
Anton et al. (2021)
4 more