› 4mz2

X-ray diffraction
1.72Å resolution

Crystal structure of the voltage-gated sodium channel beta 4 subunit extracellular domain

Released:
DOI: 10.2210/pdb4mz2/pdb
PDB entry 4mz2 coloured by chain, front view.
PDB entry 4mz2 coloured by chain, side view.
PDB entry 4mz2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystallographic insights into sodium-channel modulation by the β4 subunit.
Gilchrist J, Das S, Van Petegem F, Bosmans F
Proc Natl Acad Sci U S A 110 E5016-24 (2013)
PMID: 24297919

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184891 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sodium channel subunit beta-4 Chain: A
Molecule details ›
Chain: A
Length: 129 amino acids
Theoretical weight: 14.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IWT1 (Residues: 32-157; Coverage: 64%)
Gene name: SCN4B
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P3221
Unit cell:
a: 43.445Å b: 43.445Å c: 108.377Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.19 0.188 0.228
Expression system: Escherichia coli

Quick links

Citations

20 review citations

The hitchhiker's guide to the voltage-gated sodium channel galaxy.
Ahern et al. (2016)
19 more

8 mentions without citation

A new look at sodium channel β subunits.
Namadurai et al. (2015)
7 more