› 4mz3

X-ray diffraction
1.74Å resolution

Crystal structure of the voltage-gated sodium channel beta 4 subunit extracellular domain, C131W mutant

Released:
DOI: 10.2210/pdb4mz3/pdb
PDB entry 4mz3 coloured by chain, front view.
PDB entry 4mz3 coloured by chain, side view.
PDB entry 4mz3 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystallographic insights into sodium-channel modulation by the β4 subunit.
Gilchrist J, Das S, Van Petegem F, Bosmans F
Proc Natl Acad Sci U S A 110 E5016-24 (2013)
PMID: 24297919

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184891 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sodium channel subunit beta-4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 129 amino acids
Theoretical weight: 14.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IWT1 (Residues: 32-157; Coverage: 64%)
Gene name: SCN4B
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
1 modified residue:
Ligand CME 2 x CME

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P21
Unit cell:
a: 31.574Å b: 42.521Å c: 89.142Å
α: 90° β: 91.51° γ: 90°
R-values:
R R work R free
0.177 0.175 0.22
Expression system: Escherichia coli

Quick links

Citations

21 review citations

The hitchhiker's guide to the voltage-gated sodium channel galaxy.
Ahern et al. (2016)
20 more

2 mentions without citation

Crystallographic insights into sodium-channel modulation by the β4 subunit.
Gilchrist et al. (2013)
1 more