› 4mzv

X-ray diffraction
1.86Å resolution

Crystal structure of extracellular part of human EpCAM

Released:
DOI: 10.2210/pdb4mzv/pdb
PDB entry 4mzv coloured by chain, front view.
PDB entry 4mzv coloured by chain, side view.
PDB entry 4mzv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure and its bearing towards an understanding of key biological functions of EpCAM.
Pavšič M, Gunčar G, Djinović-Carugo K, Lenarčič B
Nat Commun 5 4764 (2014)
PMID: 25163760

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147720 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Epithelial cell adhesion molecule Chain: A
Molecule details ›
Chain: A
Length: 248 amino acids
Theoretical weight: 28.28 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P16422 (Residues: 24-265; Coverage: 83%)
Gene names: EPCAM, GA733-2, M1S2, M4S1, MIC18, TACSTD1, TROP1
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand DMU 1 x DMU
1 modified residue:
Ligand PCA 1 x PCA

Experiments and Validation Details

Entry percentile scores
X-ray source: BRUKER AXS MICROSTAR
Spacegroup: C2
Unit cell:
a: 88.022Å b: 50.385Å c: 67.828Å
α: 90° β: 128.33° γ: 90°
R-values:
R R work R free
0.196 0.194 0.249
Expression system: Spodoptera frugiperda

Quick links

Citations

7 review citations

Abnormal Glycosylation of Cancer Stem Cells and Targeting Strategies.
Khan et al. (2021)
6 more

25 mentions without citation

Revisiting the Roles of Pro-Metastatic EpCAM in Cancer.
Mohtar et al. (2020)
24 more