› 4n1n

X-ray diffraction
1.5Å resolution

Structure of Cyclophilin A in complex with Benzamide.

Released:
DOI: 10.2210/pdb4n1n/pdb
PDB entry 4n1n coloured by chain, front view.
PDB entry 4n1n coloured by chain, side view.
PDB entry 4n1n coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Mcnae IW, Dornan J, Walkinshaw MD

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158766 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidyl-prolyl cis-trans isomerase A Chain: A
Molecule details ›
Chain: A
Length: 165 amino acids
Theoretical weight: 18.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P62937 (Residues: 1-165; Coverage: 100%)
Gene names: CYPA, PPIA
Sequence domains: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
Structure domains: Cyclophilin-like

Ligands and Environments

1 bound ligand:
Ligand UNU 1 x UNU
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P212121
Unit cell:
a: 42.91Å b: 53.61Å c: 87.62Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.169 0.166 0.213
Expression system: Escherichia coli

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