4n3z

X-ray diffraction
3.1Å resolution

Crystal structure of Rabex-5delta and Rabaptin-5C21 complex

Released:
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-172244 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Rab5 GDP/GTP exchange factor Chain: A
Molecule details ›
Chain: A
Length: 310 amino acids
Theoretical weight: 36.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UJ41 (Residues: 132-455; Coverage: 62%)
Gene names: RABEX5, RABGEF1
Sequence domains:
Structure domains: VPS9 domain
Rab GTPase-binding effector protein 1 Chains: B, C
Molecule details ›
Chains: B, C
Length: 92 amino acids
Theoretical weight: 10.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15276 (Residues: 552-642; Coverage: 11%)
Gene names: RAB5EP, RABEP1, RABPT5, RABPT5A

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P3121
Unit cell:
a: 87.14Å b: 87.14Å c: 168.878Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.267 0.264 0.315
Expression system: Escherichia coli