› 4n5u

X-ray diffraction
1.46Å resolution

Crystal structure of the 4th FN3 domain of human Protein Tyrosine phosphatase, receptor type F [PSI-NYSGRC-006240]

Released:
DOI: 10.2210/pdb4n5u/pdb
PDB entry 4n5u coloured by chain, front view.
PDB entry 4n5u coloured by chain, side view.
PDB entry 4n5u coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Kumar PR, Banu R, Bhosle R, Calarese DA, Celikgil A, Chamala S, Chan MK, Chowdhury S, Fiser A, Garforth SJ, Glenn AS, Hillerich B, Khafizov K, Attonito J, Love JD, Patel H, Patel R, Seidel RD, Smith B, Stead M, Toro R, Casadevall A, Almo SC, New York Structural Genomics Research Consortium (NYSGRC), Atoms-to-Animals: The Immune Function Network (IFN)

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145340 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Receptor-type tyrosine-protein phosphatase F Chain: A
Molecule details ›
Chain: A
Length: 117 amino acids
Theoretical weight: 12.91 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P10586 (Residues: 601-705; Coverage: 6%)
Gene names: LAR, PTPRF
Sequence domains: Fibronectin type III domain
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P212121
Unit cell:
a: 36.011Å b: 39.677Å c: 68.525Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.164 0.162 0.198
Expression system: Trichoplusia ni

Quick links