› 4n6p

X-ray diffraction
1.4Å resolution

Crystal Structure of C-lobe of Bovine lactoferrin complexed with meclofenamic acid at 1.4 A resolution

Released:
DOI: 10.2210/pdb4n6p/pdb
PDB entry 4n6p coloured by chain, front view.
PDB entry 4n6p coloured by chain, side view.
PDB entry 4n6p coloured by chain, top view.
Source organism: Bos taurus
Entry authors: Gautam L, Dube D, Sinha M, Kaur P, Sharma S, Singh TP

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150261 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Lactotransferrin Chain: A
Molecule details ›
Chain: A
Length: 341 amino acids
Theoretical weight: 37.26 KDa
Source organism: Bos taurus
Expression system: Escherichia coli
UniProt:
  • Canonical: P24627 (Residues: 361-695; Coverage: 49%)
Gene name: LTF
Sequence domains: Transferrin
Structure domains: Periplasmic binding protein-like II
Lactotransferrin Chain: B
Molecule details ›
Chain: B
Length: 6 amino acids
Theoretical weight: 653 Da
Source organism: Bos taurus
Expression system: Escherichia coli
UniProt:
  • Canonical: P24627 (Residues: 700-705; Coverage: 1%)
Gene name: LTF

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
7 bound ligands:
Ligand ZN 1 x ZN
Ligand FE 1 x FE
Ligand CO3 1 x CO3
Ligand SO4 1 x SO4
Ligand NAG 1 x NAG
Ligand GOL 2 x GOL
Ligand JMS 1 x JMS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: P21
Unit cell:
a: 62.144Å b: 49.884Å c: 65.21Å
α: 90° β: 106.83° γ: 90°
R-values:
R R work R free
0.179 0.177 0.208
Expression system: Escherichia coli

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