› 4n73

X-ray diffraction
1.87Å resolution

Crystal structure of the ligand binding domain (LBD) of REV-ERB beta bound to Cobalt Protoporphyrin IX

Released:
DOI: 10.2210/pdb4n73/pdb
PDB entry 4n73 coloured by chain, front view.
PDB entry 4n73 coloured by chain, side view.
PDB entry 4n73 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of REV-ERBβ ligand-binding domain bound to a porphyrin antagonist.
Matta-Camacho E, Banerjee S, Hughes TS, Solt LA, Wang Y, Burris TP, Kojetin DJ
J Biol Chem 289 20054-66 (2014)
PMID: 24872411

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172135 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nuclear receptor subfamily 1 group D member 2 Chain: A
Molecule details ›
Chain: A
Length: 199 amino acids
Theoretical weight: 22.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q14995 (Residues: 381-578; Coverage: 34%)
Gene name: NR1D2
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand COH 1 x COH
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P21212
Unit cell:
a: 73.66Å b: 48.68Å c: 69.75Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.214 0.254
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 review citations

Targeting REV-ERBα for therapeutic purposes: promises and challenges.
Wang et al. (2020)
5 more

3 mentions without citation

Structure of REV-ERBβ ligand-binding domain bound to a porphyrin antagonist.
Matta-Camacho et al. (2014)
2 more