› 4n85

X-ray diffraction
1.6Å resolution

Crystal structure of human transthyretin

Released:
DOI: 10.2210/pdb4n85/pdb
PDB entry 4n85 coloured by chain, front view.
PDB entry 4n85 coloured by chain, side view.
PDB entry 4n85 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of human transthyretin complexed with glabridin.
Yokoyama T, Kosaka Y, Mizuguchi M
J Med Chem 57 1090-6 (2014)
PMID: 24422526

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136168 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B
Molecule details ›
Chains: A, B
Length: 159 amino acids
Theoretical weight: 17.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02766 (Residues: 1-147; Coverage: 100%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family
Structure domains: Transthyretin/hydroxyisourate hydrolase domain

Ligands and Environments

1 bound ligand:
Ligand CA 3 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-5A
Spacegroup: P21212
Unit cell:
a: 42.88Å b: 85.11Å c: 65.32Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.204 0.202 0.239
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Natural compounds as inhibitors of transthyretin amyloidosis and neuroprotective agents: analysis of structural data for future drug design.
Ciccone et al. (2020)
1 more

4 mentions without citation

Transthyretin: From Structural Stability to Osteoarticular and Cardiovascular Diseases.
Wieczorek et al. (2021)
3 more