› 4n8r

X-ray diffraction
2.03Å resolution

Crystal structure of RXRa LBD complexed with a synthetic modulator K-8008

Released:
DOI: 10.2210/pdb4n8r/pdb
PDB entry 4n8r coloured by chain, front view.
PDB entry 4n8r coloured by chain, side view.
PDB entry 4n8r coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Sulindac-derived RXRα modulators inhibit cancer cell growth by binding to a novel site.
Chen L, Wang ZG, Aleshin AE, Chen F, Chen J, Jiang F, Alitongbieke G, Zeng Z, Ma Y, Huang M, Zhou H, Cadwell G, Zheng JF, Huang PQ, Liddington RC, Zhang XK, Su Y
Chem Biol 21 596-607 (2014)
PMID: 24704507

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148730 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Retinoic acid receptor RXR-alpha Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 244 amino acids
Theoretical weight: 27.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P19793 (Residues: 223-462; Coverage: 52%)
Gene names: NR2B1, RXRA
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand K08 2 x K08
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: P21
Unit cell:
a: 51.038Å b: 99.347Å c: 93.971Å
α: 90° β: 98.68° γ: 90°
R-values:
R R work R free
0.193 0.192 0.239
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Tetrazoles via Multicomponent Reactions.
Neochoritis et al. (2019)
3 more

6 mentions without citation

Regulation of the nongenomic actions of retinoid X receptor-α by targeting the coregulator-binding sites.
Zhang et al. (2015)
5 more