4ne9

X-ray diffraction
2.6Å resolution

Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero dimer
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134047 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
Proprotein convertase subtilisin/kexin type 9 Chains: A, B
Molecule details ›
Chains: A, B
Length: 540 amino acids
Theoretical weight: 57.44 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q8NBP7 (Residues: 153-692; Coverage: 82%)
Gene names: NARC1, PCSK9, PSEC0052
Sequence domains:
Structure domains:
Proprotein convertase subtilisin/kexin type 9 Chains: C, P
Molecule details ›
Chains: C, P
Length: 152 amino acids
Theoretical weight: 17.04 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q8NBP7 (Residues: 1-152; Coverage: 18%)
Gene names: NARC1, PCSK9, PSEC0052
Sequence domains: Peptidase inhibitor I9
Structure domains: Peptidase S8 propeptide/proteinase inhibitor I9
Low-density lipoprotein receptor Chain: D
Molecule details ›
Chain: D
Length: 26 amino acids
Theoretical weight: 2.77 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P01130 (Residues: 314-339; Coverage: 3%)
Gene name: LDLR

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, FUC
2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P212121
Unit cell:
a: 126.398Å b: 131.392Å c: 134.634Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.191 0.19 0.211
Expression system: Spodoptera frugiperda