› 4nfc

X-ray diffraction
2.2Å resolution

Structure of paired immunoglobulin-like type 2 receptor (PILR )

Released:
DOI: 10.2210/pdb4nfc/pdb
PDB entry 4nfc coloured by chain, front view.
PDB entry 4nfc coloured by chain, side view.
PDB entry 4nfc coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
PILRα and PILRβ have a siglec fold and provide the basis of binding to sialic acid.
Lu Q, Lu G, Qi J, Wang H, Xuan Y, Wang Q, Li Y, Zhang Y, Zheng C, Fan Z, Yan J, Gao GF
Proc Natl Acad Sci U S A 111 8221-6 (2014)
PMID: 24843130

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193848 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Paired immunoglobulin-like type 2 receptor beta Chains: A, B
Molecule details ›
Chains: A, B
Length: 120 amino acids
Theoretical weight: 14.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UKJ0 (Residues: 32-150; Coverage: 57%)
Gene names: FDFACT, PILRB, PP1551
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P31
Unit cell:
a: 42.803Å b: 42.803Å c: 130.205Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.221 0.219 0.258
Expression system: Escherichia coli

Quick links

Citations

5 review citations

The clinical impact of glycobiology: targeting selectins, Siglecs and mammalian glycans.
Smith et al. (2021)
4 more

2 mentions without citation

PILRα and PILRβ have a siglec fold and provide the basis of binding to sialic acid.
Lu et al. (2014)
1 more