› 4njd

X-ray diffraction
2.5Å resolution

Structure of p21-activated kinase 4 with a novel inhibitor KY-04031

Released:
DOI: 10.2210/pdb4njd/pdb
PDB entry 4njd coloured by chain, front view.
PDB entry 4njd coloured by chain, side view.
PDB entry 4njd coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Discovery and the structural basis of a novel p21-activated kinase 4 inhibitor.
Ryu BJ, Kim S, Min B, Kim KY, Lee JS, Park WJ, Lee H, Kim SH, Park S
Cancer Lett 349 45-50 (2014)
PMID: 24704155

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132116 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase PAK 4 Chain: A
Molecule details ›
Chain: A
Length: 296 amino acids
Theoretical weight: 33.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O96013 (Residues: 300-591; Coverage: 49%)
Gene names: KIAA1142, PAK4
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand NJD 1 x NJD
1 modified residue:
Ligand SEP 1 x SEP

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 5C (4A)
Spacegroup: P41212
Unit cell:
a: 65.559Å b: 65.559Å c: 183.6Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.239 0.235 0.321
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Group II p21-activated kinases as therapeutic targets in gastrointestinal cancer.
Shao et al. (2016)
2 more

4 mentions without citation

Recent advances on development of p21-activated kinase 4 inhibitors as anti-tumor agents.
Li et al. (2022)
3 more