Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Granulocyte-macrophage colony-stimulating factor
- Fibronectin type III
- Fibronectin type III superfamily
- Immunoglobulin-like fold
- Four-helical cytokine-like, core
- Type I cytokine receptor, cytokine-binding domain
- Short hematopoietin receptor, family 2, conserved site
- Short hematopoietin receptor, family 1, conserved site
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-137430 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Cytokine receptor common subunit beta
Molecule details ›
Chain: A
Length: 414 amino acids
Theoretical weight: 47.26 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: GM-CSF/IL-3/IL-5 receptor common beta subunit, N-terminal
Length: 414 amino acids
Theoretical weight: 47.26 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical:
P32927 (Residues: 25-438; Coverage: 47%)
Sequence domains: GM-CSF/IL-3/IL-5 receptor common beta subunit, N-terminal
Granulocyte-macrophage colony-stimulating factor
Molecule details ›
Chain: C
Length: 127 amino acids
Theoretical weight: 14.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Granulocyte-macrophage colony-stimulating factor
Structure domains: Growth Hormone; Chain: A;
Length: 127 amino acids
Theoretical weight: 14.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P04141 (Residues: 18-144; Coverage: 100%)
Sequence domains: Granulocyte-macrophage colony-stimulating factor
Structure domains: Growth Hormone; Chain: A;
Granulocyte-macrophage colony-stimulating factor receptor subunit alpha
Molecule details ›
Chain: B
Length: 305 amino acids
Theoretical weight: 34.85 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: Interleukin-6 receptor alpha chain, binding
Structure domains: Immunoglobulins
Length: 305 amino acids
Theoretical weight: 34.85 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: P15509 (Residues: 113-400; Coverage: 76%)
Sequence domains: Interleukin-6 receptor alpha chain, binding
Structure domains: Immunoglobulins
