› 4nmx

X-ray diffraction
1.85Å resolution

PCSK9(deltaCRD) in complex with phage-derived inhibitory peptide 2-8

Released:
DOI: 10.2210/pdb4nmx/pdb
PDB entry 4nmx coloured by chain, front view.
PDB entry 4nmx coloured by chain, side view.
PDB entry 4nmx coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Identification of a small peptide that inhibits PCSK9 protein binding to the low density lipoprotein receptor.
Zhang Y, Eigenbrot C, Zhou L, Shia S, Li W, Quan C, Tom J, Moran P, Di Lello P, Skelton NJ, Kong-Beltran M, Peterson A, Kirchhofer D
J Biol Chem 289 942-55 (2014)
PMID: 24225950

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-164911 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Proprotein convertase subtilisin/kexin type 9 Chain: A
Molecule details ›
Chain: A
Length: 125 amino acids
Theoretical weight: 14.01 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q8NBP7 (Residues: 31-152; Coverage: 18%)
Gene names: NARC1, PCSK9, PSEC0052
Sequence domains: Peptidase inhibitor I9
Structure domains: Peptidase S8 propeptide/proteinase inhibitor I9
Proprotein convertase subtilisin/kexin type 9 Chain: B
Molecule details ›
Chain: B
Length: 308 amino acids
Theoretical weight: 32.84 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q8NBP7 (Residues: 153-452; Coverage: 45%)
Gene names: NARC1, PCSK9, PSEC0052
Sequence domains: Subtilase family
Structure domains: Peptidase S8/S53 domain
peptide 2-8 Chain: Z
Molecule details ›
Chain: Z
Length: 15 amino acids
Theoretical weight: 1.7 KDa

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: C2
Unit cell:
a: 95.102Å b: 70.765Å c: 70.413Å
α: 90° β: 96.08° γ: 90°
R-values:
R R work R free
0.186 0.185 0.222
Expression system: Spodoptera frugiperda

Quick links

Citations

26 review citations

PCSK9: a key modulator of cardiovascular health.
Seidah et al. (2014)
25 more

5 mentions without citation

Targeting proprotein convertase subtilisin/kexin type 9 (PCSK9): from bench to bedside.
Bao et al. (2024)
4 more