› 4nnd

X-ray diffraction
2.5Å resolution

Structural basis of PTPN18 fingerprint on distinct HER2 tyrosine phosphorylation sites

Released:
DOI: 10.2210/pdb4nnd/pdb
PDB entry 4nnd coloured by chain, front view.
PDB entry 4nnd coloured by chain, side view.
PDB entry 4nnd coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Wang H, Yang F, Yang D, Du Y

Function and Biology Details

Reactions catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138072 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tyrosine-protein phosphatase non-receptor type 18 Chains: A, B, D, G
Molecule details ›
Chains: A, B, D, G
Length: 290 amino acids
Theoretical weight: 33.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q99952 (Residues: 6-295; Coverage: 63%)
Gene names: BDP1, PTPN18
Sequence domains: Protein-tyrosine phosphatase
Structure domains: Protein tyrosine phosphatase superfamily
Receptor tyrosine-protein kinase erbB-2 Chains: C, E, F, H
Molecule details ›
Chains: C, E, F, H
Length: 6 amino acids
Theoretical weight: 876 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P04626 (Residues: 1109-1114; Coverage: 1%)
Gene names: ERBB2, HER2, MLN19, NEU, NGL

Ligands and Environments

No bound ligands
1 modified residue:
Ligand PTR 4 x PTR

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P21
Unit cell:
a: 74.102Å b: 95.284Å c: 88.161Å
α: 90° β: 94.02° γ: 90°
R-values:
R R work R free
0.264 0.262 0.291
Expression systems:
  • Escherichia coli
  • Not provided

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