› 4nr2

X-ray diffraction
2Å resolution

Crystal structure of STK4 (MST1) SARAH domain

Released:
DOI: 10.2210/pdb4nr2/pdb
PDB entry 4nr2 coloured by chain, front view.
PDB entry 4nr2 coloured by chain, side view.
PDB entry 4nr2 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Chaikuad A, Krojer T, Kopec J, von Delft F, Arrowsmith CH, Edwards AM, Bountra C, Knapp S, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171516 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase 4 18kDa subunit Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 51 amino acids
Theoretical weight: 6.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q13043 (Residues: 432-480; Coverage: 10%)
Gene names: KRS2, MST1, STK4
Sequence domains: C terminal SARAH domain of Mst1
Structure domains: p53-like tetramerisation domain

Ligands and Environments

1 bound ligand:
Ligand EDO 10 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P212121
Unit cell:
a: 55.26Å b: 63.75Å c: 144.74Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.264 0.207 0.24
Expression system: Escherichia coli BL21(DE3)

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