› 4nr6

X-ray diffraction
1.66Å resolution

Crystal structure of the bromodomain of human CREBBP in complex with an oxazepin ligand

Released:
DOI: 10.2210/pdb4nr6/pdb
PDB entry 4nr6 coloured by chain, front view.
PDB entry 4nr6 coloured by chain, side view.
PDB entry 4nr6 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Filippakopoulos P, Picaud S, Felletar I, Hay D, Fedorov O, Martin S, Chaikuad A, von Delft F, Brennan P, Arrowsmith CH, Edwards AM, Bountra C, Knapp S, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187751 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CREB-binding protein Chain: A
Molecule details ›
Chain: A
Length: 119 amino acids
Theoretical weight: 14.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q92793 (Residues: 1081-1197; Coverage: 5%)
Gene names: CBP, CREBBP
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

1 bound ligand:
Ligand 2LN 1 x 2LN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: C2
Unit cell:
a: 89.71Å b: 35.14Å c: 40.4Å
α: 90° β: 93° γ: 90°
R-values:
R R work R free
0.181 0.178 0.23
Expression system: Escherichia coli BL21(DE3)

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