› 4nt5

X-ray diffraction
3.28Å resolution

Crystal structure of human von Willebrand factor CTCK domain

Released:
DOI: 10.2210/pdb4nt5/pdb
PDB entry 4nt5 coloured by chain, front view.
PDB entry 4nt5 coloured by chain, side view.
PDB entry 4nt5 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Highly reinforced structure of a C-terminal dimerization domain in von Willebrand factor.
Zhou YF, Springer TA
Blood 123 1785-93 (2014)
PMID: 24394662

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137574 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
von Willebrand factor Chain: A
Molecule details ›
Chain: A
Length: 107 amino acids
Theoretical weight: 12.07 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P04275 (Residues: 2721-2813; Coverage: 3%)
Gene names: F8VWF, VWF

Ligands and Environments

3 bound ligands:
Ligand NAG 1 x NAG
Ligand ZN 1 x ZN
Ligand SO4 5 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P4332
Unit cell:
a: 135.34Å b: 135.34Å c: 135.34Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.226 0.224 0.248
Expression system: Homo sapiens

Quick links

Citations

9 review citations

von Willebrand factor, Jedi knight of the bloodstream.
Springer TA. (2014)
8 more

6 mentions without citation

Connective Tissue Growth Factor: From Molecular Understandings to Drug Discovery.
Chen et al. (2020)
5 more