› 4ntj

X-ray diffraction
2.62Å resolution

Structure of the human P2Y12 receptor in complex with an antithrombotic drug

Released:
DOI: 10.2210/pdb4ntj/pdb
PDB entry 4ntj coloured by chain, front view.
PDB entry 4ntj coloured by chain, side view.
PDB entry 4ntj coloured by chain, top view.
Source organisms:
Primary publication:
Structure of the human P2Y12 receptor in complex with an antithrombotic drug.
Zhang K, Zhang J, Gao ZG, Zhang D, Zhu L, Han GW, Moss SM, Paoletta S, Kiselev E, Lu W, Fenalti G, Zhang W, Müller CE, Yang H, Jiang H, Cherezov V, Katritch V, Jacobson KA, Stevens RC, Wu B, Zhao Q
Nature 509 115-8 (2014)
PMID: 24670650

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-142142 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
P2Y purinoceptor 12; Soluble cytochrome b562 Chain: A
Molecule details ›
Chain: A
Length: 466 amino acids
Theoretical weight: 53.25 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9H244 (Residues: 2-223, 224-342; Coverage: 100%)
  • Canonical: P0ABE7 (Residues: 23-128; Coverage: 100%)
Gene names: HORK3, P2RY12, cybC
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand AZJ 1 x AZJ
Ligand CLR 2 x CLR
Ligand OLC 2 x OLC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: C2
Unit cell:
a: 98.65Å b: 156.43Å c: 47.77Å
α: 90° β: 111.08° γ: 90°
R-values:
R R work R free
0.221 0.22 0.246
Expression system: Spodoptera frugiperda

Quick links

Citations

56 review citations

Nucleotide signalling during inflammation.
Idzko et al. (2014)
55 more

85 mentions without citation

Generic GPCR residue numbers - aligning topology maps while minding the gaps.
Isberg et al. (2015)
84 more