› 4nwt

X-ray diffraction
1.75Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134837 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Ig-like domain-containing protein Chain: L
Molecule details ›
Chain: L
Length: 220 amino acids
Theoretical weight: 24.34 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8TCD0 (Residues: 21-55, 56-239; Coverage: 100%)
Sequence domains:
Structure domains: Immunoglobulins
Immunoglobulin heavy constant gamma 1 Chain: H
Molecule details ›
Chain: H
Length: 233 amino acids
Theoretical weight: 24.95 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01857 (Residues: 1-105; Coverage: 26%)
Gene name: IGHG1
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ligands and Environments

3 bound ligands:
Ligand MES 2 x MES
Ligand ACT 4 x ACT
Ligand PGE 1 x PGE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: C2
Unit cell:
a: 127.72Å b: 64.36Å c: 63.81Å
α: 90° β: 108.67° γ: 90°
R-values:
R R work R free
0.152 0.15 0.181
Expression system: Homo sapiens

Quick links

Citations

7 review citations

Monoclonal antibodies: technologies for early discovery and engineering.
Kennedy et al. (2018)
6 more

1 mention without citation

Nucleotide insertions and deletions complement point mutations to massively expand the diversity created by somatic hypermutation of antibodies.
Bowers et al. (2014)