› 4nxp

X-ray diffraction
2.3Å resolution

Crystal Structure of Free T-cell Lymphoma Invasion and Metastasis-1 PDZ Domain Quadruple Mutant (QM)

Released:
DOI: 10.2210/pdb4nxp/pdb
PDB entry 4nxp coloured by chain, front view.
PDB entry 4nxp coloured by chain, side view.
PDB entry 4nxp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Distinct Roles for Conformational Dynamics in Protein-Ligand Interactions.
Liu X, Speckhard DC, Shepherd TR, Sun YJ, Hengel SR, Yu L, Fowler CA, Gakhar L, Fuentes EJ
Structure 24 2053-2066 (2016)
PMID: 27998539

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171501 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Rho guanine nucleotide exchange factor TIAM1 Chain: A
Molecule details ›
Chain: A
Length: 94 amino acids
Theoretical weight: 10.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q13009 (Residues: 841-930; Coverage: 6%)
Gene name: TIAM1
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: P3221
Unit cell:
a: 45.843Å b: 45.843Å c: 71.362Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.219 0.217 0.258
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

Emerging Themes in PDZ Domain Signaling: Structure, Function, and Inhibition.
Liu et al. (2019)
10 other articles

1 mention without citation

Distinct Roles for Conformational Dynamics in Protein-Ligand Interactions.
Liu et al. (2016)