› 4nyt

X-ray diffraction
2.25Å resolution

L-Ficolin Complexed to Phosphocholine

Released:
DOI: 10.2210/pdb4nyt/pdb
PDB entry 4nyt coloured by chain, front view.
PDB entry 4nyt coloured by chain, side view.
PDB entry 4nyt coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Human L-ficolin recognizes phosphocholine moieties of pneumococcal teichoic acid.
Vassal-Stermann E, Lacroix M, Gout E, Laffly E, Pedersen CM, Martin L, Amoroso A, Schmidt RR, Zähringer U, Gaboriaud C, Di Guilmi AM, Thielens NM
J Immunol 193 5699-708 (2014)
PMID: 25344472

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172309 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Ficolin-2 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 217 amino acids
Theoretical weight: 24.62 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q15485 (Residues: 97-313; Coverage: 75%)
Gene names: FCN2, FCNL
Sequence domains: Fibrinogen beta and gamma chains, C-terminal globular domain
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, MAN, FUC
Carbohydrate polymer
5 bound ligands:
Ligand ACT 2 x ACT
Ligand CA 4 x CA
Ligand PO4 1 x PO4
Ligand NAG 1 x NAG
Ligand PC 1 x PC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P3221
Unit cell:
a: 96.13Å b: 96.13Å c: 139.88Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.214 0.213 0.243
Expression system: Trichoplusia ni

Quick links

Citations

6 review citations

Pattern recognition receptors in health and diseases.
Li et al. (2021)
5 more