› 4o6w

X-ray diffraction
1.45Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156774 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Serine/threonine-protein kinase PLK1 Chain: A
Molecule details ›
Chain: A
Length: 237 amino acids
Theoretical weight: 27.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P53350 (Residues: 371-603; Coverage: 39%)
Gene names: PLK, PLK1
Sequence domains: POLO box duplicated region
Structure domains: POLO box domain
Peptide-Based inhibitor Chain: C
Molecule details ›
Chain: C
Length: 7 amino acids
Theoretical weight: 935 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
2 modified residues:
Ligand 2SO 1 x 2SO
Ligand TPO 1 x TPO

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P21
Unit cell:
a: 35.819Å b: 51.275Å c: 58.006Å
α: 90° β: 101.19° γ: 90°
R-values:
R R work R free
0.185 0.184 0.215
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

5 review citations

Recent Advances and New Strategies in Targeting Plk1 for Anticancer Therapy.
Lee et al. (2015)
4 more

1 mention without citation

Target Analysis and Mechanism of Podophyllotoxin in the Treatment of Triple-Negative Breast Cancer.
Zhang et al. (2020)