› 4o7q

X-ray diffraction
1.82Å resolution

Crystal Structure of the F27G AIM2 Pyrin Domain Mutant and Similarities of its Self-association to DED/DED Interactions

Released:
DOI: 10.2210/pdb4o7q/pdb
PDB entry 4o7q coloured by chain, front view.
PDB entry 4o7q coloured by chain, side view.
PDB entry 4o7q coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the F27G AIM2 PYD mutant and similarities of its self-association to DED/DED interactions.
Lu A, Kabaleeswaran V, Fu T, Magupalli VG, Wu H
J Mol Biol 426 1420-7 (2014)
PMID: 24406744

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127179 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interferon-inducible protein AIM2 Chain: A
Molecule details ›
Chain: A
Length: 94 amino acids
Theoretical weight: 10.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O14862 (Residues: 1-93; Coverage: 27%)
Gene name: AIM2
Sequence domains: PAAD/DAPIN/Pyrin domain
Structure domains: Death Domain, Fas

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P212121
Unit cell:
a: 29.94Å b: 37.95Å c: 76.95Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.18 0.178 0.238
Expression system: Escherichia coli

Quick links

Citations

19 review citations

The Structure and Dynamics of Higher-Order Assemblies: Amyloids, Signalosomes, and Granules.
Wu et al. (2016)
18 more

6 mentions without citation

International Union of Basic and Clinical Pharmacology. XCVI. Pattern recognition receptors in health and disease.
Bryant et al. (2015)
5 more