› 4o9h

X-ray diffraction
2.42Å resolution

Structure of Interleukin-6 in complex with a Camelid Fab fragment

Released:
DOI: 10.2210/pdb4o9h/pdb
PDB entry 4o9h coloured by chain, front view.
PDB entry 4o9h coloured by chain, side view.
PDB entry 4o9h coloured by chain, top view.
Source organisms:
Entry authors: Klarenbeek A, Blanchetot C, Schragel G, Sadi AS, Ongenae N, Hemrika W, Wijdenes J, Spinelli S, Desmyter A, Cambillau C, Hultberg A, Kretz-rommel A, Dreier T, De haard HJW, Roovers RC

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-209242 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Interleukin-6 Chain: A
Molecule details ›
Chain: A
Length: 186 amino acids
Theoretical weight: 21.14 KDa
Source organism: Homo sapiens
Expression system: Mammalia
UniProt:
  • Canonical: P05231 (Residues: 28-212; Coverage: 100%)
Gene names: IFNB2, IL6
Sequence domains: Interleukin-6/G-CSF/MGF family
Structure domains: Growth Hormone; Chain: A;
Heavy Chain of the Camelid Fab fragment 61H7 Chain: H
Molecule details ›
Chain: H
Length: 223 amino acids
Theoretical weight: 23.5 KDa
Source organism: Lama glama
Expression system: Mammalia
Structure domains: Immunoglobulins
Light Chain of the Camelid Fab fragment 61H7 Chain: L
Molecule details ›
Chain: L
Length: 215 amino acids
Theoretical weight: 22.53 KDa
Source organism: Lama glama
Expression system: Mammalia
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: C2
Unit cell:
a: 108.21Å b: 47.47Å c: 148.32Å
α: 90° β: 97° γ: 90°
R-values:
R R work R free
0.217 0.216 0.244
Expression system: Mammalia

Quick links