› 4ofv

X-ray diffraction
3.1Å resolution

Refinement of RAGE-DNA complex in 3S58 without DNA

Released:
DOI: 10.2210/pdb4ofv/pdb
PDB entry 4ofv coloured by chain, front view.
PDB entry 4ofv coloured by chain, side view.
PDB entry 4ofv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The specificity of DNA recognition by the RAGE receptor.
Yatime L, Andersen GR
J Exp Med 211 749-50 (2014)
PMID: 24778420

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172192 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Advanced glycosylation end product-specific receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 223 amino acids
Theoretical weight: 24.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15109 (Residues: 18-19, 23-237; Coverage: 56%)
Gene names: AGER, RAGE
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P61
Unit cell:
a: 77.92Å b: 77.92Å c: 224.387Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.221 0.22 0.24
Expression system: Escherichia coli

Quick links

Citations

7 citation in other articles

Inhibition of Caspase-1 Ameliorates Ischemia-Associated Blood-Brain Barrier Dysfunction and Integrity by Suppressing Pyroptosis Activation.
Liang et al. (2020)
6 more

4 mentions without citation

Advanced Glycation End-Products (AGEs): Formation, Chemistry, Classification, Receptors, and Diseases Related to AGEs.
Twarda-Clapa et al. (2022)
3 more