› 4oh6

X-ray diffraction
3.56Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145225 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Androgen receptor Chain: A
Molecule details ›
Chain: A
Length: 250 amino acids
Theoretical weight: 29.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P10275 (Residues: 671-920; Coverage: 27%)
Gene names: AR, DHTR, NR3C4
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Protein BUD31 homolog Chain: B
Molecule details ›
Chain: B
Length: 15 amino acids
Theoretical weight: 2.02 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P41223 (Residues: 56-70; Coverage: 10%)
Gene names: BUD31, EDG2

Ligands and Environments

2 bound ligands:
Ligand HFT 1 x HFT
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE BL13B1
Spacegroup: P212121
Unit cell:
a: 55.792Å b: 66.1Å c: 70.225Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.168 0.158 0.261
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

5 review citations

An Overview of Next-Generation Androgen Receptor-Targeted Therapeutics in Development for the Treatment of Prostate Cancer.
Mohler et al. (2021)
4 more

1 mention without citation

New Insights into the Binding Mechanism of Co-regulator BUD31 to AR AF2 Site: Structural Determination and Analysis of the Mutation Effect.
Song et al. (2020)