› 4oi7

X-ray diffraction
3.1Å resolution

RAGE recognizes nucleic acids and promotes inflammatory responses to DNA

Released:
DOI: 10.2210/pdb4oi7/pdb
PDB entry 4oi7 coloured by chain, front view.
PDB entry 4oi7 coloured by chain, side view.
PDB entry 4oi7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA.
Sirois CM, Jin T, Miller AL, Bertheloot D, Nakamura H, Horvath GL, Mian A, Jiang J, Schrum J, Bossaller L, Pelka K, Garbi N, Brewah Y, Tian J, Chang C, Chowdhury PS, Sims GP, Kolbeck R, Coyle AJ, Humbles AA, Xiao TS, Latz E
J Exp Med 210 2447-63 (2013)
PMID: 24081950

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-117913 (preferred)
Entry contents:
1 distinct polypeptide molecule
2 distinct DNA molecules
Macromolecules (3 distinct):
Advanced glycosylation end product-specific receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 223 amino acids
Theoretical weight: 24.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q15109 (Residues: 23-237; Coverage: 56%)
Gene names: AGER, RAGE
Sequence domains:
Structure domains: Immunoglobulins
5'-D(*CP*TP*GP*CP*AP*AP*CP*GP*AP*TP*GP*CP*TP*AP*CP*GP*AP*AP*CP*GP*TP*G)-3' Chain: E
Molecule details ›
Chain: E
Length: 22 nucleotides
Theoretical weight: 6.76 KDa
Source organism: Homo sapiens
Expression system: Not provided
5'-D(*CP*AP*CP*GP*TP*TP*CP*GP*TP*AP*GP*CP*AP*TP*CP*GP*TP*TP*GP*CP*AP*G)-3' Chain: F
Molecule details ›
Chain: F
Length: 22 nucleotides
Theoretical weight: 6.74 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand EDO 4 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P61
Unit cell:
a: 77.92Å b: 77.92Å c: 224.387Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.217 0.215 0.237
Expression systems:
  • Escherichia coli BL21
  • Not provided

Quick links

Citations

42 review citations

Role of advanced glycation end products in cellular signaling.
Ott et al. (2014)
41 more

4 mentions without citation

Advanced Glycation End-Products (AGEs): Formation, Chemistry, Classification, Receptors, and Diseases Related to AGEs.
Twarda-Clapa et al. (2022)
3 more