4ol0

X-ray diffraction
2.9Å resolution

Crystal structure of transportin-SR2, a karyopherin involved in human disease, in complex with Ran

Released:
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-158727 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
GTP-binding nuclear protein Ran Chain: A
Molecule details ›
Chain: A
Length: 216 amino acids
Theoretical weight: 24.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P62826 (Residues: 1-216; Coverage: 100%)
Gene names: ARA24, OK/SW-cl.81, RAN
Sequence domains: Ras family
Structure domains: P-loop containing nucleotide triphosphate hydrolases
Transportin-3 Chain: B
Molecule details ›
Chain: B
Length: 921 amino acids
Theoretical weight: 104.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y5L0 (Residues: 3-923; Coverage: 100%)
Gene names: IPO12, TNPO3
Sequence domains: Exportin 1-like protein

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 2
Spacegroup: P212121
Unit cell:
a: 74.202Å b: 109.97Å c: 148.462Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.224 0.222 0.276
Expression system: Escherichia coli