› 4om3

X-ray diffraction
2.86Å resolution

Crystal structure of human TLE1 Q-domain residues 20-156

Released:
DOI: 10.2210/pdb4om3/pdb
PDB entry 4om3 coloured by chain, front view.
PDB entry 4om3 coloured by chain, side view.
PDB entry 4om3 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular functions of the TLE tetramerization domain in Wnt target gene repression.
Chodaparambil JV, Pate KT, Hepler MR, Tsai BP, Muthurajan UM, Luger K, Waterman ML, Weis WI
EMBO J 33 719-31 (2014)
PMID: 24596249

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170059 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transducin-like enhancer protein 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 147 amino acids
Theoretical weight: 16.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q04724 (Residues: 15-156; Coverage: 18%)
Gene name: TLE1
Sequence domains: Groucho/TLE N-terminal Q-rich domain

Ligands and Environments

1 bound ligand:
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: P21212
Unit cell:
a: 49.687Å b: 89.678Å c: 130.358Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.237 0.234 0.298
Expression system: Escherichia coli

Quick links

Citations

15 review citations

Wnt some lose some: transcriptional governance of stem cells by Wnt/β-catenin signaling.
Lien et al. (2014)
14 more

2 mentions without citation

Molecular functions of the TLE tetramerization domain in Wnt target gene repression.
Chodaparambil et al. (2014)
1 more