› 4om7

X-ray diffraction
2.2Å resolution

Crystal structure of TIR domain of TLR6

Released:
DOI: 10.2210/pdb4om7/pdb
PDB entry 4om7 coloured by chain, front view.
PDB entry 4om7 coloured by chain, side view.
PDB entry 4om7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of TIR domain of TLR6 reveals novel dimeric interface of TIR-TIR interaction for toll-like receptor signaling pathway.
Jang TH, Park HH
J Mol Biol 426 3305-3313 (2014)
PMID: 25088687

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195124 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Toll-like receptor 6 Chains: A, B
Molecule details ›
Chains: A, B
Length: 179 amino acids
Theoretical weight: 21.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y2C9 (Residues: 640-796; Coverage: 21%)
Gene name: TLR6
Sequence domains: TIR domain
Structure domains: Toll/interleukin-1 receptor homology (TIR) domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 5C (4A)
Spacegroup: C2
Unit cell:
a: 127.607Å b: 44.199Å c: 75.723Å
α: 90° β: 118.9° γ: 90°
R-values:
R R work R free
0.236 0.233 0.285
Expression system: Escherichia coli

Quick links

Citations

10 review citations

Toll/interleukin-1 receptor (TIR) domain-mediated cellular signaling pathways.
Narayanan et al. (2015)
9 more

16 mentions without citation

Toll-Like Receptors: General Molecular and Structural Biology.
Behzadi et al. (2021)
15 more